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解毒消痈，截疟，润肠通便
去其滑肠之性，转为补肝肾、益精血、乌须发之要药
煎服6–12g。补益用制何首乌；解毒、润肠、截疟用生何首乌。不可长期超量服用。
For educational reference only — not medical advice.
何首乌主含二苯乙烯苷（THSG）与蒽醌类（大黄素、大黄素甲醚）；制首乌经黑豆汁九蒸九晒后蒽醌降低，补肝肾、益精血作用增强；生首乌蒽醌含量高，偏于解毒通便。
Heshouwu contains stilbene glycoside (THSG) and anthraquinones (emodin, physcion); processed heshouwu (steamed with black-bean juice) has lower anthraquinones and tonifies liver-kidney and essence; raw heshouwu retains higher anthraquinones and is used to resolve toxin and move stool.
《中国药典》以二苯乙烯苷与结合蒽醌含量作为质量指标，并区分生首乌与制首乌用量。
Chinese Pharmacopoeia uses stilbene glycoside and combined anthraquinone content as quality markers and distinguishes dosages for raw vs processed forms.
多国监管机构（中、英、加、澳等）发出何首乌肝毒性警示，尤以生品与长期大剂量风险较高。
Regulators in China, UK, Canada, Australia and elsewhere have issued hepatotoxicity warnings, especially for raw form and prolonged high-dose use.
肝病患者禁用；出现转氨酶升高、黄疸时应立即停药。
Contraindicated in hepatic disease; discontinue immediately with rising transaminases or jaundice.
This section is provided for academic reference only and does not constitute medical advice.
大便溏泄、湿痰内盛者不宜用。生何首乌有滑肠润下之力，脾虚便溏者忌生用。生品有肝毒性报告，临床补益用必须用制何首乌（黑豆汁九蒸九晒），不可混用。
现代药理及临床报告显示何首乌（尤其是生品及未规范炮制品）可引起药物性肝损伤（DILI），表现为转氨酶升高、黄疸甚至肝衰竭。临床应严格区分生制，使用规范炮制的制何首乌，避免长期大剂量服用，肝功能异常者禁用，服药期间应监测肝功能。
何首乌，气温味苦涩，苦补肾，温补肝，能收敛精气，所以养血益肝，固精益肾，健筋骨，乌髭发，为滋补良药，不寒不燥，功在地黄、天门冬诸药之上。
@misc{bencaodian-he-shou-wu,
author = {{Bencaodian Editorial}},
title = {Hé Shǒu Wū 何首乌 (Fleeceflower Root) — Polygoni Multiflori Radix},
year = {2026},
howpublished = {Bencao Dian: A Bilingual Knowledge Graph of Traditional Chinese Medicine},
url = {https://bencaodian.org/en/herbs/he-shou-wu},
urldate = {2026-04-09},
note = {CC BY-SA 4.0}
}