The representative formula for fifth-watch (pre-dawn) diarrhea from Spleen-Kidney yang vacuity. Bu Gu Zhi warms the Kidney as the primary action; Rou Dou Kou astringes the intestines as the auxiliary. A concise four-herb formula combining warming and astringency — the essential prescription for Kidney diarrhea.
Treatment Principle
温肾暖脾，涩肠止泻
Warm the Kidney and heat the Spleen, astringe the intestines and stop diarrhea
This prescription is provided only by the dispensing TCM practitioner. Take as directed; do not modify the dose or share it. If you experience any adverse effect, stop immediately and contact your practitioner. The content of this platform is educational reference, not medical advice. Bencao Dian · https://bencaodian.org · CC BY-SA 4.0
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Cite this entry
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@misc{bencaodian-si-shen-wan,
author = {{Bencaodian Editorial}},
title = {Sì Shén Wán 四神丸 (Four-Spirit Pill)},
year = {2026},
howpublished = {Bencao Dian: A Bilingual Knowledge Graph of Traditional Chinese Medicine},
url = {https://bencaodian.org/en/formulas/si-shen-wan},
urldate = {2026-04-16},
note = {CC BY-SA 4.0}
}